Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

Abstract Background Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are needed for viral attachment and invasion into host cells. Methods We exami...

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Bibliographic Details
Main Authors: Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung, U-BIOPRED Consortium
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Respiratory Research
Subjects:
ACE2
FURIN
TMPRSS2
Severe asthma
Neutrophil
Online Access:https://doi.org/10.1186/s12931-020-01605-8

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