Investigation of the Protective Effect of Thymbra Spicata L. Var Spicata and Cyclotrichium Origanifolium on Kidney in Experimental Traumatic Spinal Cord Injury

• Main Author: Figen Koç Direk
• Format: Article
• Language: English
• Published: Dicle University Medical School 2021-06-01
• Series: Dicle Medical Journal
• Subjects: spinal cord injury; kidney; antioxidant; zahter
• Online Access: http://diclemedj.org/upload/sayi/81/Dicle%20Med%20J-04672.pdf
• ISSN: 1300-2945; 1308-9889

Objective: In this study, it was aimed to investigate the potential therapeutic and protective effects of Thymbra spicata L. var. spicata (zahter) and Cyclotrichium origanifolium (mountain mint) on kidney damage after spinal cord trauma. Method: 36 Wistar Albino male rats, weighing between 250-300 g, were divided into 6 groups with 6 in each. Group 1; control, Group 2; zahter, Group 3; mountain mint, Goup 4; trauma, Group 5; trauma + zahter Group 6; trauma + mountain mint. Trauma was created by applying weight reduction method (Allen) on the spinal cord in trauma groups. At the end of one week, all rats were sacrificed after blood samples were taken by cardiac puncture under ketamine anesthesia, and kidney tissue was taken. Histopathological changes in the tissue were examined. MDA, creatinine, BUN (urea), Sodium (Na) and Potassium (K) values were measured in serum. Results: As a result of histopathological examination of the kidney tissue, it was observed that glomerular structures were atrophied, the structure of the tubules degenerated, the vessels congestioned and increased mononuclear cell infiltration in the trauma group. In microscopic examination, it was observed that in the trauma + zahter and trauma + mountain mint groups, there was an improvement in the glomerular structures compared to the trauma group, and some mononuclear cell infiltration was improved. Serum MDA, BUN (urea), Na and K values were found to be increased in the trauma group compared to the other groups (p <0.05). In addition, a decrease was observed in the trauma + zahter and trauma + mint groups, although it was not statistically significant (p> 0.05). Serum creatinine level was found to be decreased in the trauma + zahter group compared to the control group (p <0.05). Conclusıon: It was determined that Thymbra spicata L. var. spicata (zahter) and Cyclotrichium origanifolium (mountain mint) were partially effective against kidney damage due to spinal cord injury and zahter was more effective than mountain mint.