Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae)

Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae)

Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3-O-β-D-glucosyl-α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1H, 13C...

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Bibliographic Details
Main Authors: Julinton Sianturi, Mayshah Purnamasari, Tri Mayanti, Desi Harneti, Unang Supratman, Khalijah Awang, Hideo Hayashi
Format: Article
Language:English
Published: Universitas Indonesia 2015-03-01
Series:Makara Journal of Science
Subjects:
Aglaia eximia
cytotoxic activity
flavonoid compound
Meliaceae
Online Access:http://journal.ui.ac.id/index.php/science/article/view/4476/3223
Description
Summary:Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3-O-β-D-glucosyl-α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H-COSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 1.22, 42.92, and >100 mg/mL, respectively
ISSN:2339-1995
2356-0851

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