Effect of dexmedetomidine on the immune function, serum inflammatory factors and hemodynamics in elderly patients with gastric cancer

• Main Authors: Cheng-Long Liu, Fei Zhang, Jie Zheng
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-11-01
• Series: Journal of Hainan Medical University
• Subjects: Dexmedetomidine; Surgery for elderly gastric cancer; Immune function; Serum inflammatory factors; Hemodynamics
• Online Access: http://www.hnykdxxb.com/PDF/201721/26.pdf

Objective: To investigate the effect of dexmedetomidine on the immune function, serum inflammatory factors and hemodynamics in elderly patients with gastric cancer. Method: A total of 84 elderly patients with gastric cancer treated in our hospital from September 2015 to March 2017 were randomly divided into the control group and the observation group, each with 42 cases. The control group received intravenous infusion of Sodium Chloride Injection before anesthesia induction, and the observation group received dexmedetomidine intravenous infusion. The levels of hemodynamic indexes HR and MAP levels, serum inflammatory factors levels of CRP, IL-2, IL-10 levels and T lymphocyte subsets levels were compared between the two groups. Results: Compared with induction of anesthesia before, the HR level of two groups were both significantly increased at 6 h after operation, the MAP level of control group was significantly increased at 6 h after operation while was not changed significantly in the observation group. According comparison between groups at 6 h after operation, the levels of HR, MAP in observation group were significantly lower than those of the control group. Compared with induction of anesthesia before, the CRP level was significantly increased at each postoperative time point in two groups; the IL-2 level at 24 h after operation of two groups were decreased significantly, while both increased back and significantly higher than that before induction of anesthesia; the IL-10 level at 24 h after operation of two groups were increased significantly, while both decreased back and significantly lower than that before induction of anesthesia. Compared with the control group at the same time point, the CRP, IL-10 level of observation group were significantly lower than those of the control group and the IL-2 level of observation group was significantly higher than that of the control group. Compared with induction of anesthesia before, the levels of CD3 + , CD4 + , CD4 + /CD8 + of control group were significantly decreased at 6 h, 24 h, 72 h after operation and significantly decreased at 24 h after operation in observation group. 72 h after operation, the levels of CD3 + , CD4 + , CD4 + /CD8 + of observation group increased back and were not changed significantly compared with induction of anesthesia before. Compared with the control group at the same time point, 6 h, 24 h, 72 h after operation, the levels of CD3 + , CD4 + , CD4 + /CD8 + of observation group were significantly higher than that of the control group. Conclusion: Dexmedetomidine for elderly patients with gastric cancer assisted anesthesia can reduce the stress caused by surgical trauma, improve the immune level, reduce the inflammatory response, and stabilize hemodynamics of patients in the perioperative period significantly. It is worthy of clinical promotion.