Granzyme B; the chalk-mark of a cytotoxic lymphocyte
<p>Abstract</p> <p>During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2004-10-01
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| Series: | Journal of Translational Medicine |
| Online Access: | http://www.translational-medicine.com/content/2/1/36 |
| Summary: | <p>Abstract</p> <p>During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing. In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells.</p> |
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| ISSN: | 1479-5876 |