ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

Summary: Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive. Here, we identified activating transcription factor 6 (ATF6) as an important regulator of angiogenesis in the pathogenesis of AS. First, we f...

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Bibliographic Details
Main Authors: Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Biological sciences
Physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221007598

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