Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

During apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential clinical target.

Bibliographic Details
Main Authors:	Sweta Iyer, Khatira Anwari, Amber E. Alsop, Wai Shan Yuen, David C. S. Huang, John Carroll, Nicholas A. Smith, Brian J. Smith, Grant Dewson, Ruth M. Kluck
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11734

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spelling	doaj-7e08a7aefe7a40b3835bb796864f5aae2021-05-11T10:47:19ZengNature Publishing GroupNature Communications2041-17232016-05-017111010.1038/ncomms11734Identification of an activation site in Bak and mitochondrial Bax triggered by antibodiesSweta Iyer0Khatira Anwari1Amber E. Alsop2Wai Shan Yuen3David C. S. Huang4John Carroll5Nicholas A. Smith6Brian J. Smith7Grant Dewson8Ruth M. Kluck9Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchMolecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchMolecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchMonash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Monash University, MelbourneCancer and Haematology Division, The Walter and Eliza Hall Institute of Medical ResearchMonash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Monash University, MelbourneDepartment of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe UniversityDepartment of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe UniversityCell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical ResearchMolecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical ResearchDuring apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential clinical target.https://doi.org/10.1038/ncomms11734
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sweta Iyer Khatira Anwari Amber E. Alsop Wai Shan Yuen David C. S. Huang John Carroll Nicholas A. Smith Brian J. Smith Grant Dewson Ruth M. Kluck
spellingShingle	Sweta Iyer Khatira Anwari Amber E. Alsop Wai Shan Yuen David C. S. Huang John Carroll Nicholas A. Smith Brian J. Smith Grant Dewson Ruth M. Kluck Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies Nature Communications
author_facet	Sweta Iyer Khatira Anwari Amber E. Alsop Wai Shan Yuen David C. S. Huang John Carroll Nicholas A. Smith Brian J. Smith Grant Dewson Ruth M. Kluck
author_sort	Sweta Iyer
title	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_short	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_full	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_fullStr	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_full_unstemmed	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_sort	identification of an activation site in bak and mitochondrial bax triggered by antibodies
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-05-01
description	During apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential clinical target.
url	https://doi.org/10.1038/ncomms11734
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Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

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