Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

<p>Abstract</p> <p>Background</p> <p>Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or quinine resistance in malaria parasites. Next-generation sequencing technol...

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Main Authors: Hunt Paul, Martinelli Axel, Modrzynska Katarzyna, Borges Sofia, Creasey Alison, Rodrigues Louise, Beraldi Dario, Loewe Laurence, Fawcett Richard, Kumar Sujai, Thomson Marian, Trivedi Urmi, Otto Thomas D, Pain Arnab, Blaxter Mark, Cravo Pedro
Format: Article
Language:English
Published: BMC 2010-09-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/11/499

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