Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development

Genome-wide analysis of androgen receptor binding and transcriptomic analysis in mesenchymal subsets during prostate development

Prostate development is controlled by androgens, the androgen receptor (AR) and mesenchymal–epithelial signalling. We used chromatin immunoprecipitation sequencing (ChIP-seq) to define AR genomic binding in the male and female mesenchyme. Tissue- and single-cell-based transcriptional profiling was u...

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Bibliographic Details
Main Authors: Claire Nash, Nadia Boufaied, Dunarel Badescu, Yu Chang Wang, Miltiadis Paliouras, Mark Trifiro, Ioannis Ragoussis, Axel A. Thomson
Format: Article
Language:English
Published: The Company of Biologists 2019-07-01
Series:Disease Models & Mechanisms
Subjects:
ChIP-seq
Androgen receptor
RNA-seq
Single-cell RNA-seq
Mesenchyme
Prostate development
Online Access:http://dmm.biologists.org/content/12/7/dmm039297

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