Comprehensive Analysis of APA Events and Their Association With Tumor Microenvironment in Lung Adenocarcinoma

Comprehensive Analysis of APA Events and Their Association With Tumor Microenvironment in Lung Adenocarcinoma

BackgroundAlternative polyadenylation (APA) is a pervasive posttranscriptional mechanism regulating gene expression. However, the specific dysregulation of APA events and its potential biological or clinical significance in lung adenocarcinoma (LUAD) remain unclear.MethodsHere, we collected RNA-Seq...

Full description

Bibliographic Details
Main Authors:	Yuchu Zhang, Libing Shen, Qili Shi, Guofang Zhao, Fajiu Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Genetics
Subjects:	alternative polyadenylation lung adenocarcinoma immunity metabolism miRNA
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2021.645360/full

Similar Items

Four-miRNA signature as a prognostic tool for lung adenocarcinoma
by: Lin Y, et al.
Published: (2017-12-01)

The Identification of Alternative Polyadenylation in Stomach Adenocarcinomas Using the Genotype-Tissue Expression Project and the Cancer Genome Atlas– Stomach Adenocarcinoma Profiles
by: Li J, et al.
Published: (2021-09-01)

Immune-related genes with APA in microenvironment indicate risk stratification and clinical prognosis in grade II/III gliomas
by: Shengchao Xu, et al.
Published: (2021-03-01)

A panel of miRNAs derived from plasma extracellular vesicles as novel diagnostic biomarkers of lung adenocarcinoma
by: Bing Yao, et al.
Published: (2019-12-01)

Systematic identification of clinically relevant miRNAs for potential miRNA-based therapy in lung adenocarcinoma
by: Shu-Hsuan Liu, et al.
Published: (2021-09-01)

Development of a miRNA-seq based prognostic signature in lung adenocarcinoma
by: Chathura Siriwardhana, et al.
Published: (2019-01-01)

Epithelial-mesenchymal transition markers screened in a cell-based model and validated in lung adenocarcinoma
by: Jing Song, et al.
Published: (2019-07-01)

Investigation of NF-kappaB-Dependent Transcriptional and Post-Transcriptional Regulatory Networks in Late Ischemic Preconditioning
by: Tranter, Michael C.
Published: (2010)

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma
by: Shi-lu Chen, et al.
Published: (2021-03-01)

Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma
by: Chioniso Patience Masamha, et al.
Published: (2016-03-01)

Identification of tumor suppressor miRNAs by integrative miRNA and mRNA sequencing of matched tumor–normal samples in lung adenocarcinoma
by: Namhee Yu, et al.
Published: (2019-06-01)

MicroRNA‐155‐5p suppresses PD‐L1 expression in lung adenocarcinoma
by: Jiansheng Huang, et al.
Published: (2020-06-01)

Predict Colon Cancer by Pairing Plasma miRNAs: Establishment of a Normalizer-Free, Cross-Platform Model
by: Da Qin, et al.
Published: (2021-04-01)

Identification of Novel Alternative Splicing Events Associated With Tumorigenesis, Protein Modification, and Immune Microenvironment in Early-Onset Gastric Cancer
by: Jian Zhang, et al.
Published: (2021-06-01)

Modulation of untranslated region alternative polyadenylation in glioma tumorigenesis
by: Yu-Long Lan, et al.
Published: (2021-05-01)

Régulation de l'épissage et de la polyadénylation alternatifs par les agents anti-cancéreux génotoxiques
by: Tanaka, Iris
Published: (2019)

Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea
by: Vairavan Lakshmanan, et al.
Published: (2016-10-01)

MiR-1307-5p targeting TRAF3 upregulates the MAPK/NF-κB pathway and promotes lung adenocarcinoma proliferation
by: Xinyue Du, et al.
Published: (2020-10-01)

miRNA-1290 Promotes Aggressiveness in Pancreatic Ductal Adenocarcinoma by Targeting IKK1
by: Na Ta, et al.
Published: (2018-11-01)

miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma: a case–control study involving 2,740 participants
by: Chen Y, et al.
Published: (2018-06-01)

Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease
by: Radhika Patel, et al.
Published: (2019-05-01)

Alternative polyadenylation of mRNA and its role in cancer
by: Fuwen Yuan, et al.
Published: (2021-01-01)

Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast
by: Rachael Emily Turner, et al.
Published: (2021-07-01)

Useful Bicistronic Reporter System for Studying Poly(A) Site-Defining cis Elements and Regulation of Alternative Polyadenylation
by: Zhongyuan Deng, et al.
Published: (2018-01-01)

Useful Bicistronic Reporter System for Studying Poly(A) Site-Defining cis Elements and Regulation of Alternative Polyadenylation
by: Deng, Zhongyuan, et al.
Published: (2018)

Serum Exosomal miR-1290 is a Potential Biomarker for Lung Adenocarcinoma
by: Wu Y, et al.
Published: (2020-08-01)

Screening of miRNAs as Prognostic Biomarkers for Colon Adenocarcinoma and Biological Function Analysis of Their Target Genes
by: Guoliang Zheng, et al.
Published: (2021-03-01)

The DNA methylation profile of non-coding RNAs improves prognosis prediction for pancreatic adenocarcinoma
by: Jie Zhang, et al.
Published: (2019-04-01)

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs
by: Benjamin J. Harrison, et al.
Published: (2019-03-01)

Construction of a specific SVM classifier and identification of molecular markers for lung adenocarcinoma based on lncRNA-miRNA-mRNA network
by: Zhao J, et al.
Published: (2018-05-01)

MicroRNA Profiling in Oesophageal Adenocarcinoma Cell Lines and Patient Serum Samples Reveals a Role for miR-451a in Radiation Resistance
by: Frederike Butz, et al.
Published: (2020-11-01)

Putative alternative polyadenylation (APA) events in the early interaction of Salmonella enterica Typhimurium and human host cells
by: Fabian Afonso-Grunz
Published: (2015-12-01)

GENOME WIDE ANALYSES OF ALTERNATIVE POLYADENYLATION IN ARABIDOPSIS
by: Guo, Cheng
Published: (2016)

Targeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy
by: Anne-Charlotte Marsollier, et al.
Published: (2018-05-01)

Systemic Analysis of the Prognosis-Associated Alternative Polyadenylation Events in Breast Cancer
by: Yi Zhang, et al.
Published: (2020-11-01)

Construction of prognostic predictor by comprehensive analyzing alternative splicing events for colon adenocarcinoma
by: Yaqi Qu, et al.
Published: (2020-09-01)

Tumor Microenvironment
by: Azam Ahmadi, et al.
Published: (2018-12-01)

Identifying the key genes and microRNAs in prostate cancer bone metastasis by bioinformatics analysis
by: Zhiguo Zhu, et al.
Published: (2020-04-01)

Alternative Polyadenylation in response to temperature stress contributes to gene regulation in Populus trichocarpa
by: Chao Yan, et al.
Published: (2021-01-01)

Differences between Well-Differentiated Neuroendocrine Tumors and Ductal Adenocarcinomas of the Pancreas Assessed by Multi-Omics Profiling
by: Teresa Starzyńska, et al.
Published: (2020-06-01)