Differential effects of short- and long-term treatment with mepolizumab on eosinophil kinetics in blood and sputum in eosinophilic asthma

Differential effects of short- and long-term treatment with mepolizumab on eosinophil kinetics in blood and sputum in eosinophilic asthma

Summary: Mepolizumab (anti-IL-5) is a successful biological for treatment of T2/eosinophilic asthma by blocking the IL-5-eosinophil axis. The kinetics of human eosinophils in blood and sputum was determined to better understand the underlying mechanism(s). Pulse-chase labeling was performed with 6,6...

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Bibliographic Details
Main Authors: Marwan Hassani, Tamar Tak, Corneli van Aalst, Saar van Nederveen, Kiki Tesselaar, Nienke Vrisekoop, Leo Koenderman
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
Health sciences
Immunology
Respiratory medicine
Clinical medicine
Drugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008816

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