Caloric restriction delays age-related methylation drift

Caloric restriction delays age-related methylation drift

Caloric restriction has been shown to increase lifespan in mammals. Here, the authors provide evidence that age-related methylation drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results in attenuation of age-related methylation drift.

Bibliographic Details
Main Authors: Shinji Maegawa, Yue Lu, Tomomitsu Tahara, Justin T. Lee, Jozef Madzo, Shoudan Liang, Jaroslav Jelinek, Ricki J. Colman, Jean-Pierre J. Issa
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00607-3
id doaj-7df8716f28e94df0a4d186d22d31c1a2
record_format Article
spelling doaj-7df8716f28e94df0a4d186d22d31c1a22021-05-11T07:26:41ZengNature Publishing GroupNature Communications2041-17232017-09-018111110.1038/s41467-017-00607-3Caloric restriction delays age-related methylation driftShinji Maegawa0Yue Lu1Tomomitsu Tahara2Justin T. Lee3Jozef Madzo4Shoudan Liang5Jaroslav Jelinek6Ricki J. Colman7Jean-Pierre J. Issa8Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple UniversityDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer CenterFels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple UniversityFels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple UniversityFels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple UniversityDepartment of Biostatistics and Computational Biology, The University of Texas MD Anderson Cancer CenterFels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple UniversityWisconsin National Primate Research Center and Department of Cell and Regenerative Biology, University of WisconsinFels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple UniversityCaloric restriction has been shown to increase lifespan in mammals. Here, the authors provide evidence that age-related methylation drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results in attenuation of age-related methylation drift.https://doi.org/10.1038/s41467-017-00607-3
collection DOAJ
language English
format Article
sources DOAJ
author Shinji Maegawa
Yue Lu
Tomomitsu Tahara
Justin T. Lee
Jozef Madzo
Shoudan Liang
Jaroslav Jelinek
Ricki J. Colman
Jean-Pierre J. Issa
spellingShingle Shinji Maegawa
Yue Lu
Tomomitsu Tahara
Justin T. Lee
Jozef Madzo
Shoudan Liang
Jaroslav Jelinek
Ricki J. Colman
Jean-Pierre J. Issa
Caloric restriction delays age-related methylation drift
Nature Communications
author_facet Shinji Maegawa
Yue Lu
Tomomitsu Tahara
Justin T. Lee
Jozef Madzo
Shoudan Liang
Jaroslav Jelinek
Ricki J. Colman
Jean-Pierre J. Issa
author_sort Shinji Maegawa
title Caloric restriction delays age-related methylation drift
title_short Caloric restriction delays age-related methylation drift
title_full Caloric restriction delays age-related methylation drift
title_fullStr Caloric restriction delays age-related methylation drift
title_full_unstemmed Caloric restriction delays age-related methylation drift
title_sort caloric restriction delays age-related methylation drift
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-09-01
description Caloric restriction has been shown to increase lifespan in mammals. Here, the authors provide evidence that age-related methylation drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results in attenuation of age-related methylation drift.
url https://doi.org/10.1038/s41467-017-00607-3
work_keys_str_mv AT shinjimaegawa caloricrestrictiondelaysagerelatedmethylationdrift
AT yuelu caloricrestrictiondelaysagerelatedmethylationdrift
AT tomomitsutahara caloricrestrictiondelaysagerelatedmethylationdrift
AT justintlee caloricrestrictiondelaysagerelatedmethylationdrift
AT jozefmadzo caloricrestrictiondelaysagerelatedmethylationdrift
AT shoudanliang caloricrestrictiondelaysagerelatedmethylationdrift
AT jaroslavjelinek caloricrestrictiondelaysagerelatedmethylationdrift
AT rickijcolman caloricrestrictiondelaysagerelatedmethylationdrift
AT jeanpierrejissa caloricrestrictiondelaysagerelatedmethylationdrift
_version_ 1721452263898087424

Similar Items