The relationship between vitamin 25(OH)D level and hematological parameters in newly diagnosed women with fibromyalgia syndrome

• Main Authors: İlknur Aykurt Karlıbel, Lale Altan, Deniz Azkan Türe, Meliha Kasapoğlu, Hakan Demirci
• Format: Article
• Language: English
• Published: Journal of Surgery and Medicine 2021-01-01
• Series: Journal of Surgery and Medicine
• Subjects: fibromyalgia; inflammation; platelet activation; platelet distribution width; vitamin d
• Online Access: https://dergipark.org.tr/en/pub/josam/issue/59430/746743

Background/Aim: Chronic inflammation may play a role in the pathogenesis of fibromyalgia syndrome (FMS). Several hematological markers are prothrombotic, and markers of systemic inflammation. Vitamin D (VitD) level can affect FMS and has an anti-inflammatory effect. The aim of this study is to investigate the relationship between hematological parameters and VitD in FMS and its effect on disease severity. Methods: The prospective case-control study included 90 newly diagnosed female patients with FMS (group 1) and 90 healthy volunteers (group 2). Pain and fatigue were evaluated by visual analogue scale (VAS). Disease severity was evaluated by FMS Impact Questionnaire (FIQ) in FMS. Neutrophils, lymphocytes, platelets, platelet distribution width (PDW) and mean platelet volume (MPV) were obtained from complete blood count results in both groups. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were calculated. 25(OH)D concentration was measured. Patients were divided into 3 groups according to vitamin D levels (VitD < 10 ng/ml, 10-30 ng/ml and >30 ng/ml.) Results: The mean MPV and vitamin D levels were significantly higher in group 2 (P=0.001, P