Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role

Our previous studies strongly indicated that the up-regulated activity of skin fibroblast-derived elastase plays a pivotal role in wrinkling and/or sagging of the skin via the impairment of elastic fiber configuration and the subsequent loss of skin elasticity. Fortunately, we succeeded in identify...

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Bibliographic Details
Main Authors: Genji Imokawa, Hiroaki Nakajima, Koichi Ishida
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:International Journal of Molecular Sciences
Subjects:
ultraviolet A
ultraviolet B
keratinocytes
fibroblasts
elastase
neprilysin
neutral endopeptidase
Online Access:http://www.mdpi.com/1422-0067/16/4/7776

Internet

http://www.mdpi.com/1422-0067/16/4/7776

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