Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats

Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats

Abstract Background Ischemia-reperfusion injury of the spinal cord (SCII) often leads to unalterable neurological deficits, which may be associated with apoptosis induced by oxidative stress and inflammation. Astaxanthin (AST) is a strong antioxidant and anti-inflammatory agent with multitarget neur...

Full description

Bibliographic Details
Main Authors: Jian Fu, Haibin Sun, Haofei Wei, Mingjie Dong, Yongzhe Zhang, Wei Xu, Yanwei Fang, Jianhui Zhao
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Spinal cord ischemia-reperfusion injury
Astaxanthin
Oxidative stress
Inflammation
Apoptosis
Mitochondria swelling
Online Access:http://link.springer.com/article/10.1186/s13018-020-01790-8

Similar Items

Similar Items