The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conf...

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Bibliographic Details
Main Authors: Victoria M Virador, Ben Davidson, Josephine Czechowicz, Alisha Mai, Jareer Kassis, Elise C Kohn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2662420?pdf=render

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