Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers

• Main Authors: Tara Fresques, Arrianna Zirbes, Sundus Shalabi, Susan Samson, Sandy Preto, Martha R. Stampfer, Mark A. LaBarge
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-08-01
• Series: Frontiers in Cell and Developmental Biology
• Subjects: breast cancer; prevention; chemoprevention; immortality; inflammaging; warfarin
• Online Access: https://www.frontiersin.org/article/10.3389/fcell.2019.00174/full

Preventing breast cancer before it is able to form is an ideal way to stop breast cancer. However, there are limited existing options for prevention of breast cancer. Changes in the breast tissue resulting from the aging process contribute to breast cancer susceptibility and progression and may therefore provide promising targets for prevention. Here, we describe new potential targets, immortalization and inflammaging, that may be useful for prevention of age-related breast cancers. We also summarize existing studies of warfarin and metformin, current drugs used for non-cancerous diseases, that also may be repurposed for breast cancer prevention.