A simplified procedure for the preparation of 2,3-O-isopropylidene-sn-glycerol from L-arabinose.
A new procedure for the preparation of 2,3-O-isopropylidene-sn-glycerol is described. L-arabinose is converted to its 4,5-monoisopropylidene diethyl mercaptal derivative. This compound is then subjected to periodate oxidation and borohydride reduction. Following neutralization, the aceton-glycerol i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1980-02-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520398321 |
| Summary: | A new procedure for the preparation of 2,3-O-isopropylidene-sn-glycerol is described. L-arabinose is converted to its 4,5-monoisopropylidene diethyl mercaptal derivative. This compound is then subjected to periodate oxidation and borohydride reduction. Following neutralization, the aceton-glycerol is extracted from the aqueous solution into chloroform. Evaporation of the chloroform and subsequent distillation yielded pure 2,3-O-isopropylidene-sn-glycerol ([alpha]D22 = -14.5 degrees (in substance)) in an overall yield of 15-25%. |
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| ISSN: | 0022-2275 |