Sugar phosphate activation of the stress sensor eIF2B

Sugar phosphate activation of the stress sensor eIF2B

The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthe...

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Main Authors: Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong, Carmela Sidrauski
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23836-z
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spelling doaj-7dab3274bc6948168fa0acd7979be94e2021-06-13T11:16:07ZengNature Publishing GroupNature Communications2041-17232021-06-0112111210.1038/s41467-021-23836-zSugar phosphate activation of the stress sensor eIF2BQi Hao0Jin-Mi Heo1Boguslaw P. Nocek2Kevin G. Hicks3Vincent S. Stoll4Clint Remarcik5Sean Hackett6Lauren LeBon7Rinku Jain8Dan Eaton9Jared Rutter10Yao Liang Wong11Carmela Sidrauski12Calico Life Sciences LLCCalico Life Sciences LLCResearch & Development, AbbVieDepartment of Biochemistry, University of Utah School of MedicineResearch & Development, AbbVieCalico Life Sciences LLCCalico Life Sciences LLCCalico Life Sciences LLCResearch & Development, AbbVieCalico Life Sciences LLCDepartment of Biochemistry, University of Utah School of MedicineCalico Life Sciences LLCCalico Life Sciences LLCThe activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.https://doi.org/10.1038/s41467-021-23836-z
collection DOAJ
language English
format Article
sources DOAJ
author Qi Hao
Jin-Mi Heo
Boguslaw P. Nocek
Kevin G. Hicks
Vincent S. Stoll
Clint Remarcik
Sean Hackett
Lauren LeBon
Rinku Jain
Dan Eaton
Jared Rutter
Yao Liang Wong
Carmela Sidrauski
spellingShingle Qi Hao
Jin-Mi Heo
Boguslaw P. Nocek
Kevin G. Hicks
Vincent S. Stoll
Clint Remarcik
Sean Hackett
Lauren LeBon
Rinku Jain
Dan Eaton
Jared Rutter
Yao Liang Wong
Carmela Sidrauski
Sugar phosphate activation of the stress sensor eIF2B
Nature Communications
author_facet Qi Hao
Jin-Mi Heo
Boguslaw P. Nocek
Kevin G. Hicks
Vincent S. Stoll
Clint Remarcik
Sean Hackett
Lauren LeBon
Rinku Jain
Dan Eaton
Jared Rutter
Yao Liang Wong
Carmela Sidrauski
author_sort Qi Hao
title Sugar phosphate activation of the stress sensor eIF2B
title_short Sugar phosphate activation of the stress sensor eIF2B
title_full Sugar phosphate activation of the stress sensor eIF2B
title_fullStr Sugar phosphate activation of the stress sensor eIF2B
title_full_unstemmed Sugar phosphate activation of the stress sensor eIF2B
title_sort sugar phosphate activation of the stress sensor eif2b
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.
url https://doi.org/10.1038/s41467-021-23836-z
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AT jinmiheo sugarphosphateactivationofthestresssensoreif2b
AT boguslawpnocek sugarphosphateactivationofthestresssensoreif2b
AT kevinghicks sugarphosphateactivationofthestresssensoreif2b
AT vincentsstoll sugarphosphateactivationofthestresssensoreif2b
AT clintremarcik sugarphosphateactivationofthestresssensoreif2b
AT seanhackett sugarphosphateactivationofthestresssensoreif2b
AT laurenlebon sugarphosphateactivationofthestresssensoreif2b
AT rinkujain sugarphosphateactivationofthestresssensoreif2b
AT daneaton sugarphosphateactivationofthestresssensoreif2b
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AT yaoliangwong sugarphosphateactivationofthestresssensoreif2b
AT carmelasidrauski sugarphosphateactivationofthestresssensoreif2b
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