Sugar phosphate activation of the stress sensor eIF2B
The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthe...
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Bibliographic Details
| Main Authors: |
Qi Hao,
Jin-Mi Heo,
Boguslaw P. Nocek,
Kevin G. Hicks,
Vincent S. Stoll,
Clint Remarcik,
Sean Hackett,
Lauren LeBon,
Rinku Jain,
Dan Eaton,
Jared Rutter,
Yao Liang Wong,
Carmela Sidrauski |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23836-z
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