Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling

Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling

Summary: The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1−/− mice, which die in the perinatal period due to respiratory distress. Constitutive or endothelial-restricted Sash1 loss leads to a delay in m...

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Main Authors: Patrick Coulombe, Grigorios N. Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H. Kyle, Andrew I. Minchinton, R. Keith Humphries, Pamela A. Hoodless, Jeremy D.K. Parker, Joanne L. Wright, Aly Karsan
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719305042

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