Effect of limited internal fixation + external fixation combined with Taohong Siwu decoction on imaging and biochemical indexes assessment in patients of tibial plateau fracture
Objective: To study the effect of limited internal fixation + external fixation combined with Taohong Siwu decoction on imaging healing and biochemical indicators in patients with tibial plateau fracture. Methods: A total of 34 patients with Schatzker type V and VI tibial plateau fracture who wer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-08-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201615/20.pdf |
| Summary: | Objective: To study the effect of limited internal fixation + external fixation combined with
Taohong Siwu decoction on imaging healing and biochemical indicators in patients with tibial
plateau fracture. Methods: A total of 34 patients with Schatzker type V and VI tibial plateau
fracture who were treated in our hospital from March 2010 to October 2014 were selected
as the research subjects and randomly divided into combined treatment group and surgical
treatment group, anteroposterior and lateral film examination of the knee joint was performed
before and after surgery in order to make clear the imaging healing, serum was collected to
determine bone alkaline phosphatase (BALP), serum C-terminal telopeptide of collagen type
1 (β-CTX), thromboxane B2 (TXB-2) and 6-ketone prostaglandin F1α (6-Keto-PGF1α)
content. Results: One month after surgery, anteroposterior and lateral film of the knee joint of
both groups showed internal fixation and external fixation in-place, and the healing of fracture
end of combined treatment group was better than that of the surgical treatment group. Serum
β-CTX and TXB2 content as well as TXB2/6-Keto-PGF1毩 ratio of combined treatment
group 14 days after surgery were significantly lower than those on the very day after surgery
while BALP and 6-Keto-PGF1毩 content were significantly higher than those on the very day
after surgery (P<0.05); serum BALP content of surgical treatment group 14 days after surgery
was higher than that on the very day after surgery while β-CTX content was lower than that
on the very day after surgery (P<0.05), and serum TXB2 and 6-Keto-PGF1β content as well
as TXB2/6-Keto-PGF1α ratio were not significantly different from those on the very day after
surgery (P>0.05). Serum BALP and 6-Keto-PGF1α content of combined treatment group 14
days after surgery were higher than those of surgical treatment group while β-CTX and TXB2
content as well as TXB2/6-Keto-PGF1α ratio were lower than those of surgical treatment
group (P<0.05). Conclusions: Limited internal fixation + external fixation combined with
Taohong Siwu decoction can promote the healing of tibial plateau fracture, and adjusting the
osteoblast/osteoclast activity and TXA2/PGF1α balance is the functioning molecular target of
Taohong Siwu decoction. |
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| ISSN: | 1007-1237 1007-1237 |