Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival

The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are...

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Main Authors:	Je-Tae Woo, Takayuki Yonezawa, Byung-Yoon Cha, Toshiaki Teruya, Kazuo Nagai
Format:	Article
Language:	English
Published:	Elsevier 2008-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319314720

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spelling	doaj-7da2a1120095484783bb6349ad123c252020-11-25T01:20:32ZengElsevierJournal of Pharmacological Sciences1347-86132008-01-011064547554Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and SurvivalJe-Tae Woo0Takayuki Yonezawa1Byung-Yoon Cha2Toshiaki Teruya3Kazuo Nagai4Department of Biological Chemistry, Chubu University, Matsumoto 1200, Kasugai 487-8501, Japan; Corresponding author. jwoo@isc.chubu.ac.jpDepartment of Biological Chemistry, Chubu University, Matsumoto 1200, Kasugai 487-8501, JapanDepartment of Biological Chemistry, Chubu University, Matsumoto 1200, Kasugai 487-8501, JapanDepartment of Biological Chemistry, Chubu University, Matsumoto 1200, Kasugai 487-8501, JapanDepartment of Biological Chemistry, Chubu University, Matsumoto 1200, Kasugai 487-8501, JapanThe mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are target cells for anti-osteoporosis therapies. To discover new types of antiresorptive agents, we screened for natural compounds that regulate osteoclast differentiation, function, and survival. As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. In this review, we discuss the mechanisms of action of these compounds on osteoclasts. Keywords:: microbial metabolite, antiresorptive agent, bone resorption, osteoclast, osteoporosis, bone metabolismhttp://www.sciencedirect.com/science/article/pii/S1347861319314720
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Je-Tae Woo Takayuki Yonezawa Byung-Yoon Cha Toshiaki Teruya Kazuo Nagai
spellingShingle	Je-Tae Woo Takayuki Yonezawa Byung-Yoon Cha Toshiaki Teruya Kazuo Nagai Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival Journal of Pharmacological Sciences
author_facet	Je-Tae Woo Takayuki Yonezawa Byung-Yoon Cha Toshiaki Teruya Kazuo Nagai
author_sort	Je-Tae Woo
title	Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
title_short	Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
title_full	Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
title_fullStr	Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
title_full_unstemmed	Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
title_sort	pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival
publisher	Elsevier
series	Journal of Pharmacological Sciences
issn	1347-8613
publishDate	2008-01-01
description	The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are target cells for anti-osteoporosis therapies. To discover new types of antiresorptive agents, we screened for natural compounds that regulate osteoclast differentiation, function, and survival. As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. In this review, we discuss the mechanisms of action of these compounds on osteoclasts. Keywords:: microbial metabolite, antiresorptive agent, bone resorption, osteoclast, osteoporosis, bone metabolism
url	http://www.sciencedirect.com/science/article/pii/S1347861319314720
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Pharmacological Topics of Bone Metabolism: Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival

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