Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects

• Main Authors: Leila Zummo, Alessandra Maria Vitale, Celeste Caruso Bavisotto, Marco De Curtis, Rita Garbelli, Anna Teresa Giallonardo, Carlo Di Bonaventura, Martina Fanella, Everly Conway de Macario, Francesco Cappello, Alberto J. L. Macario, Antonella Marino Gammazza
• Format: Article
• Language: English
• Published: MDPI AG 2021-08-01
• Series: International Journal of Molecular Sciences
• Subjects: epilepsy; temporal lobe epilepsy; miRNA; chaperone system; molecular chaperones
• Online Access: https://www.mdpi.com/1422-0067/22/16/8601
• ISSN: 1661-6596; 1422-0067

Epilepsy is a pathologic condition with high prevalence and devastating consequences for the patient and its entourage. Means for accurate diagnosis of type, patient monitoring for predicting seizures and follow up, and efficacious treatment are desperately needed. To improve this adverse outcome, miRNAs and the chaperone system (CS) are promising targets to understand pathogenic mechanisms and for developing theranostics applications. miRNAs implicated in conditions known or suspected to favor seizures such as neuroinflammation, to promote epileptic tolerance and neuronal survival, to regulate seizures, and others showing variations in expression levels related to seizures are promising candidates as useful biomarkers for diagnosis and patient monitoring, and as targets for developing novel therapies. Components of the CS are also promising as biomarkers and as therapeutic targets, since they participate in epileptogenic pathways and in cytoprotective mechanisms in various epileptogenic brain areas, even if what they do and how is not yet clear. The data in this review should help in the identification of molecular targets among the discussed miRNAs and CS components for research aiming at understanding epileptogenic mechanisms and, subsequently, develop means for predicting/preventing seizures and treating the disease.