Sensitive Voltammetric Determination of Acetaminophen at Poly(4-vinyl pyridine)/Graphene Composite Modified Electrode

This study demonstrates the use of a selective and sensitive voltammetric sensor for determination of acetaminophen (AC). This was  performed by modifying a glassy carbon electrode with composite film of poly(4-vinylpyridine) and graphene sheet (P4VP/GR-GCE). The redox peak currents of AC increased...

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Bibliographic Details
Main Authors: Ramin M.A.Tehrani, Hanieh Ghadimi
Format: Article
Language:English
Published: Iranian Chemical Society 2016-06-01
Series:Analytical and Bioanalytical Chemistry Research
Subjects:
Online Access:http://www.analchemres.org/article_14839_bffd653db0a43709fe45dc9116f1bee3.pdf
Description
Summary:This study demonstrates the use of a selective and sensitive voltammetric sensor for determination of acetaminophen (AC). This was  performed by modifying a glassy carbon electrode with composite film of poly(4-vinylpyridine) and graphene sheet (P4VP/GR-GCE). The redox peak currents of AC increased significantly at P4VP/GR-GCE. The result was achieved by the synergistic effect of combined electron mediator property of P4VP along with remarkable physical properties of GR which improved the kinetics of the catalytic oxidation of AC. The P4VP/GR-GCE exhibited excellent sensitivity, good reproducibilityand long-termstability for measuring AC with detection limits of 3.2 nM in the linear range of 0.04-300 µM. The novel developed sensor was not interfered by physiologically common interference, viz. ascorbic acid (AA) and uric acid (UA). The P4VP/GR-GCE was also successfully applied for detection of AC in tablets and urine samples, so it is reasonable to expect its broad use as AC sensor.
ISSN:2383-093X
2383-093X