Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits

Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits

The role of NMDA receptors in learning, memory and hippocampal function has long been recognized. Post-mortem studies have indicated that the expression or subunit composition of the NMDA glutamate receptor subtype might be related to the impaired cognitive functions found in schizophrenia patients....

Full description

Bibliographic Details
Main Authors: Libor Uttl, Tomas Petrasek, Hilal Sengul, Marketa Svojanovska, Veronika Lobellova, Karel Vales, Dominika Radostova, Grygoriy Tsenov, Hana Kubova, Anna Mikulecka, Jan Svoboda, Ales Stuchlik
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
schizophrenia
animal model
dizocilpine
rats
chronic treatment
western blot
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00042/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00042/full

Similar Items