Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle

Protein synthesis is suppressed in working skeletal muscle. Teleologically, the skeletal muscle halts an ATP-consuming anabolic process such as protein synthesis to spare ATP for contractile activity during an emergency. So far, 2 mechanisms have been proposed for halting protein synthesis in workin...

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Main Author: Taro Murakami
Format: Article
Language:English
Published: Japanese Society of Physical Fitness and Sports Medicine 2012-08-01
Series:Journal of Physical Fitness and Sports Medicine
Subjects:
Online Access:https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_163/_pdf/-char/en
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spelling doaj-7d8e0fdb94854d6793ee74f32e9d6cef2021-06-02T05:16:00ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232012-08-011116316510.7600/jpfsm.1.163jpfsmRegulatory mechanisms involved in blunting protein synthesis in working skeletal muscleTaro Murakami0Department of Nutrition, Shigakkan UniversityProtein synthesis is suppressed in working skeletal muscle. Teleologically, the skeletal muscle halts an ATP-consuming anabolic process such as protein synthesis to spare ATP for contractile activity during an emergency. So far, 2 mechanisms have been proposed for halting protein synthesis in working muscle. One of these mechanisms suggests that AMPK inhibits mTORC1, which is arguably a master regulator of the initiation step in protein translation. Another theory suggests Ca2+-dependent inactivation of eukaryotic elongation factor 2 (eEF2), which regulates the elongation step in protein translation. Previous reports in the literature suggest that factors other than AMPK and/or eEF2 are involved in the suppression of protein synthesis. We have recently shown that REDD1 might also be involved in blunting protein synthesis in working muscle. Understanding these mechanisms might lead to the development of new strategies and treatments, not only for athletes but also for individuals with muscle-wasting conditions such as sarcopenia.https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_163/_pdf/-char/enmuscle protein synthesisampkeef2redd1
collection DOAJ
language English
format Article
sources DOAJ
author Taro Murakami
spellingShingle Taro Murakami
Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
Journal of Physical Fitness and Sports Medicine
muscle protein synthesis
ampk
eef2
redd1
author_facet Taro Murakami
author_sort Taro Murakami
title Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
title_short Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
title_full Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
title_fullStr Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
title_full_unstemmed Regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
title_sort regulatory mechanisms involved in blunting protein synthesis in working skeletal muscle
publisher Japanese Society of Physical Fitness and Sports Medicine
series Journal of Physical Fitness and Sports Medicine
issn 2186-8131
2186-8123
publishDate 2012-08-01
description Protein synthesis is suppressed in working skeletal muscle. Teleologically, the skeletal muscle halts an ATP-consuming anabolic process such as protein synthesis to spare ATP for contractile activity during an emergency. So far, 2 mechanisms have been proposed for halting protein synthesis in working muscle. One of these mechanisms suggests that AMPK inhibits mTORC1, which is arguably a master regulator of the initiation step in protein translation. Another theory suggests Ca2+-dependent inactivation of eukaryotic elongation factor 2 (eEF2), which regulates the elongation step in protein translation. Previous reports in the literature suggest that factors other than AMPK and/or eEF2 are involved in the suppression of protein synthesis. We have recently shown that REDD1 might also be involved in blunting protein synthesis in working muscle. Understanding these mechanisms might lead to the development of new strategies and treatments, not only for athletes but also for individuals with muscle-wasting conditions such as sarcopenia.
topic muscle protein synthesis
ampk
eef2
redd1
url https://www.jstage.jst.go.jp/article/jpfsm/1/1/1_163/_pdf/-char/en
work_keys_str_mv AT taromurakami regulatorymechanismsinvolvedinbluntingproteinsynthesisinworkingskeletalmuscle
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