Comparative analysis of biochemical parameters of atherosclerosis adiponectin and resistin in patients with diabetes mellitus and coronary heart disease

• Main Authors: Rašić D., Perić V., Rašić J., Lazić S., Nikolić G., Dejanović B.
• Format: Article
• Language: English
• Published: Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva 2015-01-01
• Series: Praxis Medica
• Subjects: adipocyte hormones; diabetes mellitus; coronary disease
• Online Access: http://scindeks-clanci.ceon.rs/data/pdf/0350-8773/2015/0350-87731503007R.pdf

The most important adipocytokines affecting the formation and the regression of atheromas plaque in the coronary blood vessels are adiponectin and resistin. The essence of this test is to determine the correlation of the leading biochemical parameters of atherosclerosis, adiponectin and resistin and determine their interdependence with other biochemical parameters in patients with diabetes mellitus and coronary heart disease. Our study group consisted of 140 patients and 40 control group (healthy), 50 with diabetes mellitus and 50 with coronary heart disease (myocardial infarction and angina pectoris). We find that the average value of adiponectin in the group with type 2 diabetes mellitus were significantly lower than in the control group (4.38 to 6.74, p = 0.001, p <0.05). In the same study group average value of resistin was significantly higher than in the control group (15.8 to 7.88, p <0.001). The average value of adiponectin and resistin in patients with myocardial infarction and angina pectoris are no different from the value obtained in diabetes mellitus (4.94 to 4.38 and p = 0.397, p> 0.05). In the same study group average value of resistin was significantly higher than in the control group (15.73 to 7.88, p = 0.001, p <0.01) and not different than in the group with diabetes mellitus. Values Pearsonovg correlation coefficient shows that the biggest falls inversely proportional dependence of adiponectin with a simultaneous increase in resistin is expressed in patients with myocardial infarction, which is expressed very good correlation coefficient (-0.36). In all the groups, shows that there is a negative correlation between resistin and adiponectin, with increasing values of resistin values of adiponectin are reduced.