Rationally designed synthetic protein hydrogels with predictable mechanical properties

Mechanical properties of protein hydrogels are critical to mimic natural tissue but correlating bulk properties on the molecular level remains challenging. Here the authors show that the hierarchy of crosslinkers and load-bearing modules on a molecular level defines the mechanical properties of the...

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Main Authors:	Junhua Wu, Pengfei Li, Chenling Dong, Heting Jiang, Bin Xue, Xiang Gao, Meng Qin, Wei Wang, Bin Chen, Yi Cao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-02917-6

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spelling	doaj-7d73dd7caa7c46a58297a09fde39dee92021-05-11T09:52:08ZengNature Publishing GroupNature Communications2041-17232018-02-019111110.1038/s41467-018-02917-6Rationally designed synthetic protein hydrogels with predictable mechanical propertiesJunhua Wu0Pengfei Li1Chenling Dong2Heting Jiang3Bin Xue4Xiang Gao5Meng Qin6Wei Wang7Bin Chen8Yi Cao9Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityDepartment of Engineering Mechanics, Zhejiang UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityDepartment of Engineering Mechanics, Zhejiang UniversityCollaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing UniversityMechanical properties of protein hydrogels are critical to mimic natural tissue but correlating bulk properties on the molecular level remains challenging. Here the authors show that the hierarchy of crosslinkers and load-bearing modules on a molecular level defines the mechanical properties of the hydrogel.https://doi.org/10.1038/s41467-018-02917-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Junhua Wu Pengfei Li Chenling Dong Heting Jiang Bin Xue Xiang Gao Meng Qin Wei Wang Bin Chen Yi Cao
spellingShingle	Junhua Wu Pengfei Li Chenling Dong Heting Jiang Bin Xue Xiang Gao Meng Qin Wei Wang Bin Chen Yi Cao Rationally designed synthetic protein hydrogels with predictable mechanical properties Nature Communications
author_facet	Junhua Wu Pengfei Li Chenling Dong Heting Jiang Bin Xue Xiang Gao Meng Qin Wei Wang Bin Chen Yi Cao
author_sort	Junhua Wu
title	Rationally designed synthetic protein hydrogels with predictable mechanical properties
title_short	Rationally designed synthetic protein hydrogels with predictable mechanical properties
title_full	Rationally designed synthetic protein hydrogels with predictable mechanical properties
title_fullStr	Rationally designed synthetic protein hydrogels with predictable mechanical properties
title_full_unstemmed	Rationally designed synthetic protein hydrogels with predictable mechanical properties
title_sort	rationally designed synthetic protein hydrogels with predictable mechanical properties
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	Mechanical properties of protein hydrogels are critical to mimic natural tissue but correlating bulk properties on the molecular level remains challenging. Here the authors show that the hierarchy of crosslinkers and load-bearing modules on a molecular level defines the mechanical properties of the hydrogel.
url	https://doi.org/10.1038/s41467-018-02917-6
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Rationally designed synthetic protein hydrogels with predictable mechanical properties

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