SAMHD1-dependent and -independent functions of HIV-2/SIV Vpx protein

SAMHD1-dependent and -independent functions of HIV-2/SIV Vpx protein

Both HIV and SIV encode a unique set of accessory proteins that enhance viral replication in the host. Two similar accessory proteins, Vpx and Vpr, are encoded by HIV-2. In contrast, HIV-1 encodes Vpr but not Vpx. Recent studies have indicated that Vpx counteracts a particular host restriction facto...

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Bibliographic Details
Main Authors: Mikako eFujita, Masako eNomaguchi, Akio eAdachi, Masami eOtsuka
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Microbiology
Subjects:
HIV-2
Reverse Transcription
Vpr
nuclear import
SIV
dNTP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00297/full

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