A Green Synthesis and Antibacterial Activity of N-Arylsulfonylhydrazone Compounds

A Green Synthesis and Antibacterial Activity of N-Arylsulfonylhydrazone Compounds

A green method has been developed for the synthesis of N-arylsulfonylhydrazones via a simple grindstone procedure. By grinding mixtures of benzensulfonyl hydrazides and a series of aryl aldehydes or ketones in the mortar using L-tyrosine as catalyst, 24 N-arylsulfonylhydrazones were synthesized in a...

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Bibliographic Details
Main Authors: Yang Qian, Hao Wangwang, He Yangqing, Zhang Qian, Yu Xiaojiao, Hua Yaobing
Format: Article
Language:English
Published: De Gruyter 2019-12-01
Series:Heterocyclic Communications
Subjects:
solvent-free
n-arylsulfonylhydrazone
l-tyrosine
grindstone method
antibacterial activities
Online Access:https://doi.org/10.1515/hc-2019-0023
Description
Summary:A green method has been developed for the synthesis of N-arylsulfonylhydrazones via a simple grindstone procedure. By grinding mixtures of benzensulfonyl hydrazides and a series of aryl aldehydes or ketones in the mortar using L-tyrosine as catalyst, 24 N-arylsulfonylhydrazones were synthesized in a few minutes with high yield. All compounds were screened for their antibacterial activities. Most of them exhibit some antibacterial activities especially for 3d, 3l and 3v showing high activity against Staphylococcus aureus and Escherichia coli.
ISSN:2191-0197

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