Dynamic Modeling of CHO Cell Metabolism Using the Hybrid Cybernetic Approach With a Novel Elementary Mode Analysis Strategy

Dynamic Modeling of CHO Cell Metabolism Using the Hybrid Cybernetic Approach With a Novel Elementary Mode Analysis Strategy

Chinese hamster ovary (CHO) cell culture has a major importance on the production of biopharmaceuticals, including recombinant therapeutic proteins such as monoclonal antibodies (MAb). Mathematical modeling of biological systems can successfully assess metabolism complexity while providing logical a...

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Bibliographic Details
Main Authors: Juan A. Martínez, Dubhe B. Bulté, Martha A. Contreras, Laura A. Palomares, Octavio T. Ramírez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
elementary mode analysis
dynamic modeling
cybernetic modeling
CHO metabolism
metabolic engineering
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00279/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00279/full

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