Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors

Here, the authors model the collecting duct system in kidneys by taking ureteric bud (UB) progenitor cells from both mouse and human primary tissues, as well as from hESC and hiPSC to generate organoids, which can model congenital anomalies of the kidney and urinary tract.

Bibliographic Details
Main Authors:	Zipeng Zeng, Biao Huang, Riana K. Parvez, Yidan Li, Jyunhao Chen, Ariel C. Vonk, Matthew E. Thornton, Tadrushi Patel, Elisabeth A. Rutledge, Albert D. Kim, Jingying Yu, Brendan H. Grubbs, Jill A. McMahon, Nuria M. Pastor-Soler, Kenneth R. Hallows, Andrew P. McMahon, Zhongwei Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23911-5

id	doaj-7d4f8c87de714171bfaad82e1c28c88c
record_format	Article
spelling	doaj-7d4f8c87de714171bfaad82e1c28c88c2021-06-20T11:13:33ZengNature Publishing GroupNature Communications2041-17232021-06-0112111510.1038/s41467-021-23911-5Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitorsZipeng Zeng0Biao Huang1Riana K. Parvez2Yidan Li3Jyunhao Chen4Ariel C. Vonk5Matthew E. Thornton6Tadrushi Patel7Elisabeth A. Rutledge8Albert D. Kim9Jingying Yu10Brendan H. Grubbs11Jill A. McMahon12Nuria M. Pastor-Soler13Kenneth R. Hallows14Andrew P. McMahon15Zhongwei Li16USC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaDeptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaDivision of Maternal Fetal Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaDeptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern CaliforniaDeptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaDivision of Maternal Fetal Medicine, Keck School of Medicine, University of Southern CaliforniaDeptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaDeptartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern CaliforniaUSC/UKRO Kidney Research Center, Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern CaliforniaHere, the authors model the collecting duct system in kidneys by taking ureteric bud (UB) progenitor cells from both mouse and human primary tissues, as well as from hESC and hiPSC to generate organoids, which can model congenital anomalies of the kidney and urinary tract.https://doi.org/10.1038/s41467-021-23911-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zipeng Zeng Biao Huang Riana K. Parvez Yidan Li Jyunhao Chen Ariel C. Vonk Matthew E. Thornton Tadrushi Patel Elisabeth A. Rutledge Albert D. Kim Jingying Yu Brendan H. Grubbs Jill A. McMahon Nuria M. Pastor-Soler Kenneth R. Hallows Andrew P. McMahon Zhongwei Li
spellingShingle	Zipeng Zeng Biao Huang Riana K. Parvez Yidan Li Jyunhao Chen Ariel C. Vonk Matthew E. Thornton Tadrushi Patel Elisabeth A. Rutledge Albert D. Kim Jingying Yu Brendan H. Grubbs Jill A. McMahon Nuria M. Pastor-Soler Kenneth R. Hallows Andrew P. McMahon Zhongwei Li Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors Nature Communications
author_facet	Zipeng Zeng Biao Huang Riana K. Parvez Yidan Li Jyunhao Chen Ariel C. Vonk Matthew E. Thornton Tadrushi Patel Elisabeth A. Rutledge Albert D. Kim Jingying Yu Brendan H. Grubbs Jill A. McMahon Nuria M. Pastor-Soler Kenneth R. Hallows Andrew P. McMahon Zhongwei Li
author_sort	Zipeng Zeng
title	Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
title_short	Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
title_full	Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
title_fullStr	Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
title_full_unstemmed	Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
title_sort	generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Here, the authors model the collecting duct system in kidneys by taking ureteric bud (UB) progenitor cells from both mouse and human primary tissues, as well as from hESC and hiPSC to generate organoids, which can model congenital anomalies of the kidney and urinary tract.
url	https://doi.org/10.1038/s41467-021-23911-5
work_keys_str_mv	AT zipengzeng generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT biaohuang generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT rianakparvez generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT yidanli generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT jyunhaochen generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT arielcvonk generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT matthewethornton generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT tadrushipatel generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT elisabetharutledge generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT albertdkim generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT jingyingyu generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT brendanhgrubbs generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT jillamcmahon generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT nuriampastorsoler generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT kennethrhallows generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT andrewpmcmahon generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors AT zhongweili generationofpatternedkidneyorganoidsthatrecapitulatetheadultkidneycollectingductsystemfromexpandableuretericbudprogenitors
_version_	1721370347286036480

Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors

Similar Items