Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett Syndrome model mice

Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett Syndrome model mice

Rett Syndrome (RTT) is a progressive neurological disorder primarily caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). The heterozygous female brain consists of mosaic of neurons containing both wildtype MeCP2 (MeCP2+) and mutant MeCP2 (MeCP2-). 3-dimensional morphologic...

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Bibliographic Details
Main Authors: Leslie eRietveld, David P Stuss, David eMcPhee, Kerry R. Delaney
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dendrites
Rett Syndrome
MeCP2
pyramidal neuron
X-Linked Genetic Disease
Sholl analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00145/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00145/full

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