Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

<p>Abstract</p> <p>Background</p> <p>P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the prolifera...

Full description

Bibliographic Details
Main Authors:	Rolletschek Alexandra, Solozobova Valeriya, Blattner Christine
Format:	Article
Language:	English
Published:	BMC 2009-06-01
Series:	BMC Cell Biology
Online Access:	http://www.biomedcentral.com/1471-2121/10/46

Similar Items

The role of p53 in the embryonic stem cell response to DNA damage
by: Corbet, Sula Wendeline
Published: (1999)

Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?
by: Melissa Rodrigues, et al.
Published: (2019-05-01)

p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration
by: Matthew J. Geden, et al.
Published: (2021-01-01)

The role of MYCN in p53 activation and the downstream response to p53 after DNA damage in neuroblastoma
by: Bell, Emma
Published: (2007)

Regulation of p53 by E3s
by: Mengwu Pan, et al.
Published: (2021-02-01)

Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.
by: Matthew L Hirsch, et al.
Published: (2011-01-01)

DNA-Damage-Induced Alternative Splicing of p53
by: Jing Chen, et al.
Published: (2021-01-01)

Transcription Factor Lbx1 Expression in Mouse Embryonic Stem Cell-Derived Phenotypes
by: Stefanie Schmitteckert, et al.
Published: (2011-01-01)

Novel Interplay between p53 and HO-1 in Embryonic Stem Cells
by: Ayelén Toro, et al.
Published: (2021-12-01)

Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage.
by: Ling Wang, et al.
Published: (2013-01-01)

p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
by: Boyd, Scott D. (Scott Dexter), 1970-
Published: (2006)

DNA damage responses in human induced pluripotent stem cells and embryonic stem cells.
by: Olga Momcilovic, et al.
Published: (2010-10-01)

p53 and responses to DNA damage in small airway epithelium
by: Armit, Christopher James
Published: (2001)

VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila
by: Ya-Chu Chang, et al.
Published: (2021-07-01)

Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality
by: Yamanaka, Yasunari
Published: (2010)

p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture
by: Aline Rangel-Pozzo, et al.
Published: (2020-02-01)

Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells
by: Menno ter Huurne, et al.
Published: (2020-02-01)

The tumour suppressor CYLD regulates the p53 DNA damage response
by: Vanesa Fernández-Majada, et al.
Published: (2016-08-01)

Mechanisms underlying the prevention of DNA damage-induced apoptosis by p53
by: 黃聖哲
Published: (2003)

p53 mRNA Metabolism Links with the DNA Damage Response
by: Sivakumar Vadivel Gnanasundram, et al.
Published: (2021-09-01)

Influence of extracellular factors on p53-mediated DNA damage responses
by: Carrera, Samantha
Published: (2013)

Dynamics of p53 signalling in response to single-strand DNA damage
by: Monteiro, Emanuela
Published: (2015)

Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage.
by: Kaspar Burger, et al.
Published: (2018-02-01)

Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA
by: Jorge Mata-Garrido, et al.
Published: (2018-07-01)

Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging.
by: Claudia E Rübe, et al.
Published: (2011-03-01)

High mobility group box 1 protein (HMGB1) stimulates the nuclear accumulation of p53
by: Maria Schröder, et al.
Published: (2019-01-01)

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.
by: Abhinav K Jain, et al.
Published: (2012-01-01)

p53 coordinates glucose and choline metabolism during the mesendoderm differentiation of human embryonic stem cells
by: Gaoyang Zhu, et al.
Published: (2020-12-01)

Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in mice.
by: Stephen Lyle, et al.
Published: (2014-01-01)

RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response
by: Toshinori Ozaki, et al.
Published: (2013-01-01)

GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis.
by: Pei Du, et al.
Published: (2013-01-01)

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
by: Jun Tang, et al.
Published: (2013-01-01)

The roles of p53 and DNA damage in B-cell chronic lymphocytic leukaemia
by: Crawford, Clark
Published: (2009)

Modulation of the p53 response : effects of DNA damage and MDM-2 overexpression
by: Ditzel, Mark Clifford
Published: (2000)

Multinucleation associated DNA damage blocks proliferation in p53-compromised cells
by: Madeleine Hart, et al.
Published: (2021-04-01)

Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway.
by: Da-yong Zhang, et al.
Published: (2011-01-01)

Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability
by: Kurt Jacobs, et al.
Published: (2016-03-01)

Nuclear Localization of p38 MAPK in Response to DNA Damage
by: C. David Wood, Tina M. Thornton, Guadalupe Sabio, Roger A. Davis, Mercedes Rincon
Published: (2009-01-01)

The Roles of DNA Methylation and P53 in the Gene Regulation of Proliferating Cell Nuclear Antigen
by: Liu, Yie-Wen, et al.
Published: (1994)

Modeling the role of p53 pulses in DNA damage- induced cell death decision
by: Cui Jun, et al.
Published: (2009-06-01)

Cannot write session to /tmp/vufind_sessions/sess_mmnd9cnmjfji0nf8ntnk1pdr4a