| Summary: | This article reviews the current status of H2 receptor antagonists,
omeprazole, sucralfate and misoprostol as therapeutic options for the prophylaxis
and treatment of nonsteroidal anti-inflammatory drug (NSAID)-induced
gastrointestinal ulceration. The efficacy of the Hz receptor antagonists appears
to be restricted to prophylaxis and treatment of NSAID-induced duodenal ulcer
disease. Omeprazole may have a place in the future treatment of NSAID-induced
gastric ulcers. However, more studies are necessary to examine this drug's efficacy
in both the prophylaxis and treatment of NSAID-induced ulceration. Sucralface
improves symptoms, but does not appear to have any effect on improving gastric
mucosal damage when compared to placebo. It may, however, be useful in the
treatment of NSAID-induced duodenal ulcers. Misoprostol is effective in both
the prophylaxis and treatment of NSAID-induced gastric ulcers; however, its
exact role in the prophylaxis and treatment of NSAlD-induced duodenal ulcers
remains to be defined.
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