A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis

For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis...

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Main Authors: Maxim Moreau, Jean-Pierre Pelletier, Bertrand Lussier, Marc-André d’Anjou, Laurent Blond, Johanne-Martel Pelletier, Jérôme R. E. del Castillo, Eric Troncy
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/180453
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spelling doaj-7d2da8c41b2e4f4d8036e71d340aece82020-11-25T00:34:26ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/180453180453A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine OsteoarthritisMaxim Moreau0Jean-Pierre Pelletier1Bertrand Lussier2Marc-André d’Anjou3Laurent Blond4Johanne-Martel Pelletier5Jérôme R. E. del Castillo6Eric Troncy7Osteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaHôpital Vétérinaire Rive-Sud, 7415 Taschereau, Brossard, QC, J4Y 1A2, CanadaClinique Vétérinaire Languedocia, 395 Ruc Maurice Béjart, 34080 Montpellier, FranceOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaFor many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.http://dx.doi.org/10.1155/2013/180453
collection DOAJ
language English
format Article
sources DOAJ
author Maxim Moreau
Jean-Pierre Pelletier
Bertrand Lussier
Marc-André d’Anjou
Laurent Blond
Johanne-Martel Pelletier
Jérôme R. E. del Castillo
Eric Troncy
spellingShingle Maxim Moreau
Jean-Pierre Pelletier
Bertrand Lussier
Marc-André d’Anjou
Laurent Blond
Johanne-Martel Pelletier
Jérôme R. E. del Castillo
Eric Troncy
A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
BioMed Research International
author_facet Maxim Moreau
Jean-Pierre Pelletier
Bertrand Lussier
Marc-André d’Anjou
Laurent Blond
Johanne-Martel Pelletier
Jérôme R. E. del Castillo
Eric Troncy
author_sort Maxim Moreau
title A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
title_short A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
title_full A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
title_fullStr A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
title_full_unstemmed A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
title_sort posteriori comparison of natural and surgical destabilization models of canine osteoarthritis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.
url http://dx.doi.org/10.1155/2013/180453
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