A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis...
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doaj-7d2da8c41b2e4f4d8036e71d340aece82020-11-25T00:34:26ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/180453180453A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine OsteoarthritisMaxim Moreau0Jean-Pierre Pelletier1Bertrand Lussier2Marc-André d’Anjou3Laurent Blond4Johanne-Martel Pelletier5Jérôme R. E. del Castillo6Eric Troncy7Osteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaHôpital Vétérinaire Rive-Sud, 7415 Taschereau, Brossard, QC, J4Y 1A2, CanadaClinique Vétérinaire Languedocia, 395 Ruc Maurice Béjart, 34080 Montpellier, FranceOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaOsteoarthritis Research Unit, Université de Montréal Hospital Centre, Notre-Dame Hospital, 1560 Sherbrooke St. East, Montreal, QC, H2L 4M1, CanadaFor many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought.http://dx.doi.org/10.1155/2013/180453 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maxim Moreau Jean-Pierre Pelletier Bertrand Lussier Marc-André d’Anjou Laurent Blond Johanne-Martel Pelletier Jérôme R. E. del Castillo Eric Troncy |
spellingShingle |
Maxim Moreau Jean-Pierre Pelletier Bertrand Lussier Marc-André d’Anjou Laurent Blond Johanne-Martel Pelletier Jérôme R. E. del Castillo Eric Troncy A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis BioMed Research International |
author_facet |
Maxim Moreau Jean-Pierre Pelletier Bertrand Lussier Marc-André d’Anjou Laurent Blond Johanne-Martel Pelletier Jérôme R. E. del Castillo Eric Troncy |
author_sort |
Maxim Moreau |
title |
A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis |
title_short |
A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis |
title_full |
A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis |
title_fullStr |
A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis |
title_full_unstemmed |
A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis |
title_sort |
posteriori comparison of natural and surgical destabilization models of canine osteoarthritis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA). Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning. The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model. Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning. In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function. A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials. In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function. The translation potential of these models to the human OA condition is underlined. A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies. Ultimately, a better prediction of outcomes for human clinical trials would be brought. |
url |
http://dx.doi.org/10.1155/2013/180453 |
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