L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats

L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats

Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation mediated by the P450 enzyme system. The aim of the present study was to evaluate the influence of L-arginine supplementation, a precursor for the sy...

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Bibliographic Details
Main Authors:	Natália Valadares de Moraes, Mateus Machado Bergamaschi, Maria de Lourdes Pires Bianchi, Juliana Bordinassi Bragheto, Wilson Roberto Malfará, Regina Helena Costa Queiroz
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2012-03-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Dapsona Metemoglobinemia L-arginina Óxido nítrico L-NAME Dapsone Methemoglobinemia L-arginine Nitric oxide
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100010

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