Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors

Three-Dimensional Quantitative Structural Activity Relationship (3D-QSAR) Studies of Some 1,5-Diarylpyrazoles: Analogue Based Design of Selective Cyclooxygenase-2 Inhibitors

Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of new non-steroidal anti-inflammatory drugs (NSAID). 3D-QSAR studies have been performed on a series of 1,5-diarylpyrazoles that act as selective cyclooxygenase-2 (COX-2) inhibitors, using three differen...

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Bibliographic Details
Main Authors: Hosahalli S. Subramanya, Jagarlapudi A. R. P. Sarma, Dayam Raveendra, Ram K. R. Jetti, Bulusu Gopalakrishnan, Gautam R. Desiraju
Format: Article
Language:English
Published: MDPI AG 2000-07-01
Series:Molecules
Subjects:
NSAID design
selective COX-2 inhibitors
3D-QSAR
CoMFA
MFA
RSA
Online Access:http://www.mdpi.com/1420-3049/5/7/945/

Internet

http://www.mdpi.com/1420-3049/5/7/945/

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