Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery system (catheter and light diffuser) suitable for...

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Bibliographic Details
Main Authors: Matthieu Zellweger, Ying Xiao, Manish Jain, Marie-Noëlle Giraud, Andreas Pitzschke, Matthieu de Kalbermatten, Erwin Berger, Hubert van den Bergh, Stéphane Cook, Georges Wagnières
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Applied Sciences
Subjects:
light distributor radiometry
intra-arterial
photodynamic therapy
atherosclerosis
Online Access:https://www.mdpi.com/2076-3417/10/12/4304
Description
Summary:Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery system (catheter and light diffuser) suitable for intra-arterial PDT by using a planar imaging goniometer to measure the full radiance longitudinal and angular profiles at the surface of the diffuser at 652 nm. The results show that the system emits almost Lambertian and “top hat” profiles, an interesting feature to determine the light dosimetry in the many vascular applications of PDT.
ISSN:2076-3417

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