BMP2 Is Related to Hirschsprung’s Disease and Required for Enteric Nervous System Development

BMP2 Is Related to Hirschsprung’s Disease and Required for Enteric Nervous System Development

The enteric nervous system (ENS) is derived from neural crest cells (NCCs). Defects in ENS NCCs colonizing in the intestines lead to an absence of enteric ganglia in the colon and results in Hirschsprung’s disease (HSCR). Bone morphogenetic proteins (BMPs) play diverse roles in the proliferation, mi...

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Bibliographic Details
Main Authors: Sizhou Huang, Yi Wang, Lingfei Luo, Xiaoqing Li, Xianqing Jin, Shuangshuang Li, Xiaoping Yu, Min Yang, Zhenhua Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
BMP2
GDNF
Hirschsprung’s disease
enteric nervous system
development
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00523/full

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