Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages

Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages

Summary: In hypoxic and inflamed tissues, oxygen (O2)-dependent antimicrobial defenses are impaired due to a shortage of O2. To gain insight into the mechanisms that control bacterial infection under hypoxic conditions, we infected macrophages with the obligate intracellular pathogen Coxiella burnet...

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Bibliographic Details
Main Authors: Inaya Hayek, Fabian Fischer, Jan Schulze-Luehrmann, Katja Dettmer, Katharina Sobotta, Valentin Schatz, Lisa Kohl, Katharina Boden, Roland Lang, Peter J. Oefner, Stefan Wirtz, Jonathan Jantsch, Anja Lührmann
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471930289X

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http://www.sciencedirect.com/science/article/pii/S221112471930289X

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