Pelletization by Extrusion-Spheronization- A detailed review

Pelletization by Extrusion-Spheronization- A detailed review

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Oral multiparticulate drug system (e.g. pellets, granules) in comparison to single unit dosage form offer biopharmaceutical advantages in terms of more even and predictable drug distribution in enteric system. Extrusion spheronization is one of the most commonly used techniques in the formulation of...

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Main Author: NAGASAMY VENKATESH DHANDAPANI
Format: Article
Language:English
Published: Society for the Improvement of Science (SACSIS) 2012-10-01
Series:All Results Journals: Biol
Subjects:
Extrusion, spheronization, multiparticulate, pellet
Online Access:http://arjournals.com/index.php/Biol/article/view/68
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spelling doaj-7d13956bdbda4ccbb84cb2006db06ff92020-11-25T02:48:05ZengSociety for the Improvement of Science (SACSIS)All Results Journals: Biol2172-47842012-10-0132102321Pelletization by Extrusion-Spheronization- A detailed reviewNAGASAMY VENKATESH DHANDAPANI0JSS COLLEGE OF PHARMACY, ROCKLANDS, POST BOX NO.20, ELK HILL ROAD, OOTACAMUND - 643001. TAMIL NADU. INDIAOral multiparticulate drug system (e.g. pellets, granules) in comparison to single unit dosage form offer biopharmaceutical advantages in terms of more even and predictable drug distribution in enteric system. Extrusion spheronization is one of the most commonly used techniques in the formulation of such multiparticulate beads and pellets providing sustained and controlled release or modified release drug delivery. This review outlines the various steps involved in the extrusion spheronization process, the excipients used in such formulations along with some modifications and various processing variables affecting the quality of pellets formed. In addition, an overview of the methods available for the quality check of the pellets is reviewed.http://arjournals.com/index.php/Biol/article/view/68Extrusion, spheronization, multiparticulate, pellet
collection DOAJ
language English
format Article
sources DOAJ
author NAGASAMY VENKATESH DHANDAPANI
spellingShingle NAGASAMY VENKATESH DHANDAPANI
Pelletization by Extrusion-Spheronization- A detailed review
All Results Journals: Biol
Extrusion, spheronization, multiparticulate, pellet
author_facet NAGASAMY VENKATESH DHANDAPANI
author_sort NAGASAMY VENKATESH DHANDAPANI
title Pelletization by Extrusion-Spheronization- A detailed review
title_short Pelletization by Extrusion-Spheronization- A detailed review
title_full Pelletization by Extrusion-Spheronization- A detailed review
title_fullStr Pelletization by Extrusion-Spheronization- A detailed review
title_full_unstemmed Pelletization by Extrusion-Spheronization- A detailed review
title_sort pelletization by extrusion-spheronization- a detailed review
publisher Society for the Improvement of Science (SACSIS)
series All Results Journals: Biol
issn 2172-4784
publishDate 2012-10-01
description Oral multiparticulate drug system (e.g. pellets, granules) in comparison to single unit dosage form offer biopharmaceutical advantages in terms of more even and predictable drug distribution in enteric system. Extrusion spheronization is one of the most commonly used techniques in the formulation of such multiparticulate beads and pellets providing sustained and controlled release or modified release drug delivery. This review outlines the various steps involved in the extrusion spheronization process, the excipients used in such formulations along with some modifications and various processing variables affecting the quality of pellets formed. In addition, an overview of the methods available for the quality check of the pellets is reviewed.
topic Extrusion, spheronization, multiparticulate, pellet
url http://arjournals.com/index.php/Biol/article/view/68
work_keys_str_mv AT nagasamyvenkateshdhandapani pelletizationbyextrusionspheronizationadetailedreview
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