Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Abstract Background Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small vessel disease (CSVD). CCH is strongly associated with blood–brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, the effects of CCH on BBB integrity and components and the ce...

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Bibliographic Details
Main Authors: Zhengyu Sun, Chenhao Gao, Dandan Gao, Ruihua Sun, Wei Li, Fengyu Wang, Yanliang Wang, Huixia Cao, Guoyu Zhou, Jiewen Zhang, Junkui Shang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Fluids and Barriers of the CNS
Subjects:
Cerebral small vessel disease
Chronic cerebral hypoperfusion
BBB permeability
BBB protection
Pericyte
Endothelial transcytosis
Online Access:https://doi.org/10.1186/s12987-021-00255-2

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