SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation

Abstract Background Metabolic reprogramming is an important characteristic of tumors. In the progression of pituitary adenomas (PA), abnormal glucose metabolism has been confirmed by us before. However, whether cholesterol metabolism is involved in the process of PA remains unclear. This study aimed...

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Bibliographic Details
Main Authors: Xiao Ding, Kexia Fan, Jintao Hu, Zhenle Zang, Shunli Zhang, Yin Zhang, Zhichao Lin, Xiangdong Pei, Xin Zheng, Feng Zhu, Hui Yang, Song Li
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cholesterol
Growth
Hedgehog signaling
Pituitary adenomas
SCP2
Online Access:http://link.springer.com/article/10.1186/s13046-019-1411-9

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