Antimicrobial Activity of Fractions of Ethyl Acetate Extract of Cladosporium oxysporum, An Endophytic Fungus Derived from Alyxia reinwardtii

• Main Authors: Dwi Hartanti, July Supriyanto, Noor Erma N Sugijanto
• Format: Article
• Language: English
• Published: Badan Penelitian dan Pengembangan Kesehatan 2016-09-01
• Series: Jurnal Kefarmasian Indonesia
• Subjects: Alyxia reinwardtii; antimicrobial; Cladosporium oxysporum; endophytic fungi
• Online Access: http://ejournal.litbang.kemkes.go.id/index.php/jki/article/view/5413

The endophytic fungi <em>Cladosporium oxysporum</em> was isolated from medicinal plants <em>Alyxia reinwardtii</em>. The antimicrobial activity of fractions of ethyl acetate extract and also antioxidant and antimicrobial activities of fraction 7 of ethyl acetate extract of (AR-7) were determined in this study. Antimicrobial activity was determined by TLC bioautography and disc diffusion methods. Antioxidant activity was determined by TLC-DPPH autography assay. The fractions of ethyl acetate extract of <em>C. oxysporum</em> at dose of 100 mg/ml were active as antimicrobial against  <em>S. aureus</em>, <em>E. coli</em> and <em>C. albicans</em> in disc diffusion method test. Fraction AR-7 was active as antioxidant in TLC-DPPH autography assay. Fraction AR-7 was active as antimicrobial against <em>S. aureus</em>, but was not active against another tested microoorganisms in TLC-bioautography