Development and characterisation of semisolid systems to deliver propolis in the oral cavity

Pharmaceutical formulations containing poloxamer 407 (P407), Carbopol 934P (C934P) or gelatin (GELA), with ethanolic propolis extract (PE), were designed for the treatment of oral mucosal diseases. PE was produced and its quality was assessed by measuring its specific gravity, pH, weight of dry resi...

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Main Authors: A.N. Hirata, M.L. Bruschi
Format: Article
Language:English
Published: São Paulo State University (UNESP) 2010-01-01
Series:Revista de Ciências Farmacêuticas Básica e Aplicada
Subjects:
Online Access:http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/408
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spelling doaj-7d03e616be304a58abdd2cb12b29795b2021-01-25T14:18:26ZengSão Paulo State University (UNESP)Revista de Ciências Farmacêuticas Básica e Aplicada1808-45322179-443X2010-01-01311408Development and characterisation of semisolid systems to deliver propolis in the oral cavityA.N. HirataM.L. BruschiPharmaceutical formulations containing poloxamer 407 (P407), Carbopol 934P (C934P) or gelatin (GELA), with ethanolic propolis extract (PE), were designed for the treatment of oral mucosal diseases. PE was produced and its quality was assessed by measuring its specific gravity, pH, weight of dry residue and total flavonoid content. Monopolymeric and binary polymeric formulations were prepared and their gelling temperature (Tsol/gel), pH, continuous flow rheology and mucoadhesion were studied. PE exhibited good quality and the formulations were easy to prepare and showed a wide range of consistency. Most of the formulations showed thermoresponsive behaviour and only those containing 15% P407, plus 0.20% C934P or 1.0 % GELA, displayed Tsol/gel suitable for application to the oral mucosa. Monopolymeric formulations, containing C934P or GELA, and binary formulations exhibited pseudoplastic flow and low degrees of thixotropy. Monopolymeric formulations containing P407 exhibited pseudoplastic flow and rheopexy. The mucoadhesive properties of the systems could not be assessed. Fragments of formulation were found to remain stuck to parts of the mucin disc, owing to cohesive failure of the samples and of the sample/mucin interface. The data obtained on these formulations indicate a potentially useful role in the treatment of oral mucosal diseases.http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/408propolis. mucoadhesion. poloxamer 407. carbopol 934p. gelatin.
collection DOAJ
language English
format Article
sources DOAJ
author A.N. Hirata
M.L. Bruschi
spellingShingle A.N. Hirata
M.L. Bruschi
Development and characterisation of semisolid systems to deliver propolis in the oral cavity
Revista de Ciências Farmacêuticas Básica e Aplicada
propolis. mucoadhesion. poloxamer 407. carbopol 934p. gelatin.
author_facet A.N. Hirata
M.L. Bruschi
author_sort A.N. Hirata
title Development and characterisation of semisolid systems to deliver propolis in the oral cavity
title_short Development and characterisation of semisolid systems to deliver propolis in the oral cavity
title_full Development and characterisation of semisolid systems to deliver propolis in the oral cavity
title_fullStr Development and characterisation of semisolid systems to deliver propolis in the oral cavity
title_full_unstemmed Development and characterisation of semisolid systems to deliver propolis in the oral cavity
title_sort development and characterisation of semisolid systems to deliver propolis in the oral cavity
publisher São Paulo State University (UNESP)
series Revista de Ciências Farmacêuticas Básica e Aplicada
issn 1808-4532
2179-443X
publishDate 2010-01-01
description Pharmaceutical formulations containing poloxamer 407 (P407), Carbopol 934P (C934P) or gelatin (GELA), with ethanolic propolis extract (PE), were designed for the treatment of oral mucosal diseases. PE was produced and its quality was assessed by measuring its specific gravity, pH, weight of dry residue and total flavonoid content. Monopolymeric and binary polymeric formulations were prepared and their gelling temperature (Tsol/gel), pH, continuous flow rheology and mucoadhesion were studied. PE exhibited good quality and the formulations were easy to prepare and showed a wide range of consistency. Most of the formulations showed thermoresponsive behaviour and only those containing 15% P407, plus 0.20% C934P or 1.0 % GELA, displayed Tsol/gel suitable for application to the oral mucosa. Monopolymeric formulations, containing C934P or GELA, and binary formulations exhibited pseudoplastic flow and low degrees of thixotropy. Monopolymeric formulations containing P407 exhibited pseudoplastic flow and rheopexy. The mucoadhesive properties of the systems could not be assessed. Fragments of formulation were found to remain stuck to parts of the mucin disc, owing to cohesive failure of the samples and of the sample/mucin interface. The data obtained on these formulations indicate a potentially useful role in the treatment of oral mucosal diseases.
topic propolis. mucoadhesion. poloxamer 407. carbopol 934p. gelatin.
url http://rcfba.fcfar.unesp.br/index.php/ojs/article/view/408
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