Valproate-associated reversible encephalopathy in a 3-year-old girl with Pallister-Killian syndrome
Thorsten Gerstner, Nellie Bell, Stephan A KoenigUniversity Children’s Hospital, Mannheim, GermanyAbstract: Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes. The drug is usually well...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2008-06-01
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| Series: | Therapeutics and Clinical Risk Management |
| Online Access: | http://www.dovepress.com/valproate-associated-reversible-encephalopathy-in-a-3-year-old-girl-wi-a1890 |
| Summary: | Thorsten Gerstner, Nellie Bell, Stephan A KoenigUniversity Children’s Hospital, Mannheim, GermanyAbstract: Valproic acid (VPA) is considered to be a drug of first choice for the therapy of generalized and focal epilepsies, including special epileptic syndromes. The drug is usually well tolerated, rare serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulapathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy. We report a case of VPA-associated encephalopathy without hyperammonemia in a 3-year-old girl with Pallister-Killian-Syndrom, combined with a mild hepatopathy and thrombopathy. After withdrawal of VPA, the clinical symptoms and the electroencephalography-alterations vanished rapidly.Keywords: pallister-killian, valproate, encephalopathy, EEG, ammonia |
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| ISSN: | 1176-6336 1178-203X |