Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury.

Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury.

Age-related macular degeneration (AMD), a complex disease involving genetic variants and environmental insults, is among the leading causes of blindness in Western populations. Genetic and histologic evidence implicate the complement system in AMD pathogenesis; and smoking is the major environmental...

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Bibliographic Details
Main Authors: Alex Woodell, Beth Coughlin, Kannan Kunchithapautham, Sarah Casey, Tucker Williamson, W Drew Ferrell, Carl Atkinson, Bryan W Jones, Bärbel Rohrer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692454?pdf=render

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