SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women

SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women

SERine Protein INhibitor-A1 (SERPINA1) is an inducible blood cell gene coding for alpha1-antitrypsin (AAT), a plasma protease inhibitor whose circulating levels are raised during inflammation, infection and advanced pregnancy. DNA methylation has been suggested to play a role in SERPINA1 gene expres...

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Bibliographic Details
Main Authors: John Charles Rotondo, Lucia Oton-Gonzalez, Rita Selvatici, Paola Rizzo, Rita Pavasini, Gianluca Calogero Campo, Carmen Lanzillotti, Chiara Mazziotta, Monica De Mattei, Mauro Tognon, Fernanda Martini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SERPINA1
Alpha1-AntiTrypsin
methylation
epigenetics
peripheral blood mononuclear cell
pregnancy
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.550543/full

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